Transcranial Doppler and vasodilators therapy as predictors of early outcome in acute ischemic stroke

Abstract

The clinical impact of risk factors and vasodilator therapy in prevention of acute ischemic stroke remains uncertain. Ischemic stroke was considered severe in the Romanian Stroke Prevention Society. Poor outcome are at 10 days after onset of a minor ischaemic stroke or a transient ischaemic attack. The association between predictors and outcome was assessed using unconditional multivariable logistic regression. Covariates used included age, stroke severity, diabetes mellitus, coronary artery disease, atrial fibrillation, premorbid hypertension and hyper-lipidemia and the results pursuited by Transcranial Doppler, analyzing the Pendefunda’s Index. Three hundred and twenty-eight patients were included. Compared to patients predicted as normal who were found to have an increased stroke risk, our patients decreasd the clinical aspects after the vasodilators administration, while the reactivity in the first week after stroke onset was found to result in a decreased risk. However, neither of these findings remained significant after adjustment for the described covariates if we haven’t test the best reactivity to the drugs.